MDMA Wikipedia

August 18, 2022 0 COMMENT 5 Views

Researchers and addiction specialists widely consider ecstasy a hard drug. Know the symptoms of an overdose and ask for help right away if you believe you or someone you’re with is having one. Keep in mind that you’ll likely feel some unpleasant side effects as part of the ecstasy experience, such as nausea and vomiting, racing heartbeat, and sweating.

Side effects

Reaching out for help from friends and family can be a great way to gain support. If you communicate your problems about ecstasy and express the desire for help, you can avoid substance use disorders. It typically takes minutes before the effects of ecstasy are felt. Popular with young people since the 1980s, raves are parties often held Ecstasy ingredients in locations such as warehouses, nightclubs, and fields.

Repeated studies show that MDMA can make it easier for someone to approach therapy with vulnerability and an open mind. It may be able to help those dealing with trauma to feel safe and capable of breaking out of harmful thought patterns. Mostly known as a ‘party drug,’ MDMA may also have use in therapy for PSTD, anxiety, eating disorders, and more.

WHAT IS ECSTASY?

In some places, the police do not arrest bystanders or those who overdose; in other areas, they might. Taking ecstasy leads to feelings of euphoria, happiness, and well-being in which you feel drawn to or connected to other people as if you love them. You may feel a need to touch and be touched, and you’ll experience sexual arousal and a heightening of your senses. Ecstasy has several effects during the hours it’s active in your system.

What is molly made of?

While you may not get addicted to ecstasy, using it does increase your risk for substance use disorder, especially if you struggle to control your use of ecstasy. That can lead to serious difficulties in your daily life, such as at your job, in your relationships, and in maintaining your emotional well-being. Even though ecstasy includes addictive ingredients, there is very little research to prove that you can get addicted to the drug. Research shows drugs such as cocaine are more likely to cause addiction than ecstasy. When talking to the dispatcher, try to not use terms such as “drugs” or “overdose.” Instead, tell them the symptoms that you can see are happening, such as seizures and not breathing.

  • It typically takes minutes before the effects of ecstasy are felt.
  • In its original form, it was known as “MDMA.” It was used in 1953 by the US Army in psychological warfare tests, and then resurfaced in the 1960s as a psychotherapy medication to “lower inhibitions.”1 It wasn’t until the 1970s that MDMA started being used as a party drug.
  • The process also poses extreme health hazards due to exposure to toxic chemicals and the risk of explosion.
  • The NIH Clinical Center (the research hospital of NIH) is open.

” the answer points to clandestine and highly dangerous environments. The Food and Drug Administration (FDA) has designated MDMA-assisted psychotherapy for people with PTSD as a breakthrough therapy. There are ongoing clinical studies to test how well this treatment might work. Fentanyl can make drugs it’s mixed with, including MDMA, more dangerous. Often, people who purchase MDMA and other drugs are unaware those drugs have been cut with fentanyl.

  • More than 22 million of those surveyed said they have tried ecstasy at some point in their lives.
  • Most of the cases of serious toxicity or fatality have involved blood levels ranging from 0.5 mg/L to 10 mg/L, that is, up to 40 times higher than the usual recreational range.
  • Taking too much ecstasy can lead to a potentially fatal overdose.
  • However, at higher doses the massive release of serotonin not only gives rise to acute psychotic symptoms (as described earlier) but also causes chemical damage to the cells that released it.
  • Whether you’ve been using ecstasy, molly, or any MDMA-related substances, it’s never too late to start over.

What else can be found in MDMA?

Although there are conflicting theories concerning the mechanism of this neurotoxicity,4,27,63 it is clearly related to the excessive metabolic activity and neurotransmitter release in the serotonergic and, possibly, the dopaminergic neurons. This involves either taking three or more tablets of ecstasy at the same time or taking ecstasy with LSD, marijuana, cocaine, alcohol, or other drugs. Sometimes, the drugs are taken at different times throughout the evening as a way of modifying the high. For example, someone may take ecstasy first, then take amphetamines when the ecstasy starts to wear off. Later, they might follow this with alcohol, marijuana, or other drugs. When alcohol is involved, you are more likely to get dehydrated.

United Nations (2006), Recommended Methods for the Identification and analysis of amphetamine, methamphetamine and their ring-substituted analogues in seized materials (revised and updated), Manual for Use by National Drug Testing Laboratories, United Nations, New York. And Widdop, B, (eds.) (2004), Clarke’s analysis of drugs and poisons, 3rd edn, Vol. If you choose to take ecstasy, use it with as much precaution as possible.

Health Conditions

Molly can appear as white powder, crystals, or colorful pressed tablets, often with logos. For example, pressed ecstasy pills may contain MDMA, but they could also include meth, fentanyl, or entirely different drugs. Most MDMA is made in illegal labs located in Southeast Asia, Europe, or even domestic operations in the U.S. These labs lack any regulatory oversight, and the final product is often cut with additional substances to maximize profit.

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A major limitation of these studies is that, even if they demonstrate decreased numbers of serotonin cells and reduced serotonin system function in the brains of MDMA users, they cannot prove that the MDMA use caused the changes. Like the amphetamines, MDMA and its related compounds are amines that can exist either as free bases or as salts of various acids. The free bases are volatile and, indeed, amphetamine itself was first marketed in this form in an inhaler, for use as a nasal decongestant. Molly is often marketed as the pure form of MDMA, while ecstasy is usually pressed into tablets that may include other drugs. If you or someone you love is struggling with ecstasy or molly use, Asana Recovery offers evidence-based treatment designed to address both the physical and emotional aspects of addiction.

MDMA is readily absorbed from the intestinal tract and reaches its peak concentration in the plasma about 2 hours after oral administration.21,22 Doses of 50 mg, 75 mg and 125 mg to healthy human volunteers produced peak blood concentrations of 106 ng/mL, 131 ng/mL and 236 ng/mL respectively. These concentrations are quite low, because the drug passes readily into the tissues, and much of it is bound to tissue constituents. It is helpful to remember these peak concentrations for comparison with the levels found in patients who have suffered the serious and sometimes fatal adverse effects described later in this review. Taking an adulterated drug can lead to unexpected and unwelcome side effects and may increase its potential health risks. Over the past decade, illegally made opioids like fentanyl have been increasingly found in the drug supply, and have contributed to a dramatic rise in drug overdose deaths in the United States. MDMA and its related compounds are generally produced as racemic mixtures, but the stereoisomers differ from each other in several important respects.

MDMA

Ecstasy differs from amphetamine and methamphetamine in one important respect. 1, it has a methylenedioxy (-O-CH2-O-) group attached to positions 3 and 4 of the aromatic ring of the amphetamine molecule (i.e., it is “ring-substituted”). In this respect, it resembles the structure of the hallucinogenic material mescaline. As a result, the pharmacological effects of MDMA (and MDEA) are a blend of those of the amphetamines and mescaline, as will be described in later sections of this review. Since the late 1980s, Ecstasy has become an embracive “marketing” term for drug dealers selling “Ecstasy-type” drugs that may, in fact, contain very little or no MDMA at all. And while MDMA itself can produce harmful effects, what is called Ecstasy today can contain a wide mixture of substances—from LSD, cocaine, heroin, amphetamine and methamphetamine, to rat poison, caffeine, dog deworming substances, etc.

Despite the cute logos dealers put on the pills, this is what makes Ecstasy particularly dangerous; a user never really knows what he is taking. The dangers are increased when users increase the dose seeking a previous high, not knowing they may be taking an entirely different combination of drugs. Taking too much ecstasy can lead to a potentially fatal overdose. Its most dangerous consequence is hyperthermia — a sudden and severe rise in body temperature. This is made more likely by overexerting yourself physically while on ecstasy, for example, by dancing all night at a rave or in other hot environments. This spike in body temperature can lead to the failure of multiple organs, including the kidney and liver, as well as the failure of your cardiovascular system and muscle breakdown.

Some people who use MDMA do report symptoms of an MDMA-related substance use disorder.10 These symptoms include continued use despite negative side effects, tolerance—which is needing to take increasingly larger amounts of a drug for the same effects—withdrawal side effects, and craving. High doses of ecstasy can cause a spike in your body temperature. This can cause heart, liver, or kidney failure or even death. Some of the metabolites of MDMA are still pharmacologically active, especially its first metabolite, MDA, so that the duration of action may be somewhat longer than the duration of MDMA itself in the body. MDMA is a drug that’s commonly thought of as a party drug and is known for producing feelings of pleasure, energy, and positive emotion, along with altered sensory perception.

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